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In Pharmacology, Loewe Additivity is one of several common reference models used for measuring the effects of drug combinations. Loewe additivity is based on the idea that an agent should not have synergistic interactions with itself or like agents. To better understand the model of Loewe Additivity, an additive drug could be shown with a basic formula: If drug x and drug y are ''similar'' drugs, a dose of x and y (at equal concentration) will replicate the effect of double the dose (2x), of either drug. IF x=y , THEN x+y → 2x. The reverse of this scenario is known as hyper-antagonism. ==References== * William R Greco, Gregory Bravo, and John Parsons "The Search for Synergy: A Critical Review from a Response Surface Perspective", ''Pharmacological Reviews'' 47(2) 331-385 (1995) * Loewe and Muischnek. "Effect of combinations: mathematical basis of the problem" ''Arch. Exp. Pathol. Pharmakol.'' 114: 313-326, 1926 * Pamela J. Yeh, Matthew J. Hegreness, Aviva Presser Aiden & Roy Kishony "Nature Reviews Microbiology" 7, 460-466 (June 2009) 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Loewe additivity」の詳細全文を読む スポンサード リンク
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